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Aims: Penile cancer is an uncommon malignancy in Western countries. There are known premalignant lesions that can progress to invasive penile cancer, namely carcinoma in situ (CIS) of the glans. Treatment options for this disease include topical chemotherapy and laser ablation, but the published literature demonstrates limited efficacy for these approaches. Surgical techniques with penile-preserving approaches are performed with the goal of removing the entire tumor and preserving as much of penis as possible. There are no large, randomized studies comparing treatment options for these lesions, and reports concerning the surgical approaches are scarce.
Presentation of Case: In this study, we present a case report of a patient with CIS of the glans penis surgically treated with glans resurfacing.
Discussion and Conclusions: There were no complications during follow-up, and after 20 months, the patient has no evidence of disease recurrence, has preserved urinary and erectile functions and is currently satisfied with the cosmetic appearance.
CIS treatment with glans resurfacing allows the maintenance penile length and function with a good aesthetic result without compromising oncologic control. This approach also allows an accurate staging of the disease and assessment of the treatment efficacy.
Hakenberg OW CE, Minhas S, Necchi A, Protzel C, Watkin N. EAU guidelines on penile cancer. European Association of Urology; 2019.
Shabbir M, Muneer A, Kalsi J, Shukla CJ, Zacharakis E, Garaffa G, et al. Glans resurfacing for the treatment of carcinoma in situ of the penis: surgical technique and outcomes. Eur Urol. 2011;59(1):142-147.
Minhas S, Manseck A, Watya S, Hegarty PK. Penile cancer--prevention and premalignant conditions. Urology. 2010; 76(2 Suppl 1):S24-35.
Salim A, Leman JA, McColl JH, Chapman R, Morton CA. Randomized comparison of photodynamic therapy with topical 5-fluorouracil in Bowen's disease. Br J Dermatol. 2003;148(3):539-543.
van Bezooijen BP, Horenblas S, Meinhardt W, Newling DW. Laser therapy for carcinoma in situ of the penis. J Urol. 2001;166(5):1670-1671.
Alnajjar HM, Lam W, Bolgeri M, Rees RW, Perry MJ, Watkin NA. Treatment of carcinoma in situ of the glans penis with topical chemotherapy agents. Eur Urol. 2012;62(5):923-928.
Hadway P, Corbishley CM, Watkin NA. Total glans resurfacing for premalignant lesions of the penis: initial outcome data. BJU Int. 2006;98(3):532-536.
Palminteri E, Berdondini E, Lazzeri M, Mirri F, Barbagli G. Resurfacing and recon-struction of the glans penis. Eur Urol. 2007;52(3):893-898.
Chipollini J, Yan S, Ottenhof SR, Zhu Y, Draeger D, Baumgarten AS et al. Surgical management of penile carcinoma in situ: results from an international collaborative study and review of the literature. BJU Int. 2018;121(3):393-398.
Ayres BE, Law W, Al-Najjar HM, Corbishley CM, Perry MJA, Watkin NA. Glans resurfacing – a new penile preserving option for superficially invasive penile cancer. Eur Urol Suppl. 2011;10: 340.
Hakansson U, Kirrander P, Uvelius B, Baseckas G, Torbrand C. Organ-sparing reconstructive surgery in penile cancer: Initial experiences at two Swedish referral centres. Scand J Urol. 2015;49(2):149-154.