Journal of Cancer and Tumor International 2019-11-20T08:09:28+00:00 Journal of Cancer and Tumor International Open Journal Systems <p style="text-align: justify;"><strong>Journal of Cancer and Tumor International (ISSN: 2454-7360)</strong>&nbsp;aims to publish high quality papers (<a href="/index.php/JCTI/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Cancer and&nbsp;Tumor research’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed, open access INTERNATIONAL journal.</p> Medullary Thyroid Carcinoma Metastatic to the Breast: Case Report 2019-11-20T08:09:27+00:00 Amal Halim Eman M. Ibrahim Fatma I. El-saeed Enas A. Abd Elgalil Hosam Halim <p><strong>Aims:</strong> To spot the light on metastatic tumors to the breast which represent only 0.5-1.5% of breast malignancies to avoid misdiagnosis as primary breast tumors.&nbsp;</p> <p><strong>Presentation of the Case:</strong> 45-year-old female was referred to the Oncology Department of Meet Ghmmr Oncology Center in November 2017 after total thyroidectomy followed by cervical lymph node dissection for medullary thyroid carcinoma (MTC) 1 year ago at Oncology Center Mansoura University. The panel recommended postoperative radiotherapy. One month after the end of radiotherapy, she complained of frequent headache attacks and abdominal pain. CT was done in February 2018 revealed metastasis to the brain, lung, liver and ovaries. After the fifth cycle of chemotherapy, a progressively enlarging left breast mass appeared, that proved to be metastatic MTC.</p> <p><strong>Discussion:</strong> MTC is a neuroendocrine tumor of the thyroid gland. Breast is an unusual metastatic site for MTC. Consequently, breast masses should be evaluated with caution, especially in the presence of a known primary malignancy. Histopathologic examination is the key diagnostic tool.</p> <p><strong>Conclusion:</strong> Metastasis to the breast should be considered in the differential diagnosis of a breast mass in a patient with a past history of MTC. Histopathologic examination and proper panel of immunohistochemical markers are fundamental for diagnosis to prevent unneeded surgery.</p> 2019-08-22T00:00:00+00:00 ##submission.copyrightStatement## Body Mass Index and Age Correlation with Prostate-specific Antigen Density as Prostate Cancer Risk Indicators in a Screened Male University Population in Nigeria: A Pilot Study 2019-11-20T08:09:28+00:00 Eyam Sunday Eyam Ima-Abasi E. Bassey Edoise M. Isiwele Eyam Lilian Eberechukwu <p><strong>Background: </strong>Prostate-specific antigen density (PSAD) is one of the means of improving PSA sensitivity as a marker of a prostate cancer diagnosis. However, this ability is perceived to be obscured by certain factors such as high body mass index and age in Caucasian and western populations, which tends to reduce its sensitivity and lead to misclassification of at-risk patients for prostate cancer.</p> <p><strong>Aim:</strong> We studied the correlation of body mass index (BMI) and age with prostate-specific antigen density (PSAD) as indicators of prostate cancer risk in a screened male population(40 years and above) in the University of Calabar, Nigeria.</p> <p><strong>Study Design: </strong>A cross-sectional analytical study with consecutive participant recruitment.</p> <p><strong>Place and Duration of Study: </strong>The study was carried out in the University of Calabar Medical centre during a medical outreach.</p> <p><strong>Materials and Methods:</strong> The study involved sixty-one (61) healthy male participants. BMI was mathematically determined from the weight and height and was categorized as underweight, normal weight, overweight and obesity based on the WHO classification with values of &lt;18.5, 18.5-24.9, 25.0-29.9, and ≥30 (Kg/m<sup>2</sup>) respectively. Blood samples were collected and analyzed for PSA and transrectal ultrasound scan was done to estimate the prostate volume and was used to calculate the prostate-specific antigen density.</p> <p><strong>Results:</strong> Over 67% of participants had PSA values below 4.0 ng/ml, 14.8% between 4.0-10.0 ng/ml, and 18% above 10.0 ng/ml. Body mass index (BMI) assessment revealed that 1.6% of the sampled population had BMI &lt;18.5 Kg/m<sup>2</sup>, 32.8% had BMI between 18.5 Kg/m<sup>2</sup> and 24.9 Kg/m<sup>2</sup>, while 50.8% were noticed to have a BMI of between 25.0 Kg/m<sup>2</sup> and 29.9 Kg/m<sup>2</sup>, and 14.8% had BMI of 30 Kg/m<sup>2</sup> and above.</p> <p><strong>Conclusion:</strong> There was an inverse correlation of BMI with prostate-specific antigen density (PSAD) and a direct correlation of age with PSAD in this study of Nigerian men.</p> 2019-08-09T00:00:00+00:00 ##submission.copyrightStatement## Assessment of Quality of Life of Cervical Cancer Patients Using ECOG-Performance Status Scale 2019-11-20T08:09:27+00:00 Shubham Lingappanoor Geetha Rani Manupati Vasthalya Meesala Padma Yaragani Brahmani Bachu Shyam Sunder Anchuri <p><strong>Background: </strong>Cervical cancer is becoming one of the emerging health burdens for womenhood and India accounts for&nbsp;one-third of the cervical cancer deaths&nbsp;globally. More than 80% of women with cervical cancer are diagnosed at an advanced stage. In this study, we aimed to assess the Quality of Life (QOL) of patients with cervical cancer after treatment and to examine the factors affecting their QOL.</p> <p><strong>Materials and Methods: </strong>This is a retrospective observational study, included 218 cervical cancer patients. The study was conducted in a tertiary care hospital in Warangal of Telangana State. The impact of socioeconomic factors and clinical factors on the QOL of the patients were studied using Eastern Cooperative Oncology Group-Performance status (ECOG-PS) scale. The protocol was approved by KIEC-KMC, Warangal. The statistical analysis was performed by using Fischer's Exact test, a value of p&lt;.05 was considered as significant.</p> <p><strong>Results: </strong>Out of 218 patients 189 were alive and 29 were deceased. Patient of age group 21-40 years, patients from urban areas, from upper socioeconomic status (SES), patients with literacy, without any social habits had good QOL, where as patients in labour forces had poor QOL and are statistically significant. Patients with early stage at diagnosis and patients underwent surgical treatment along with chemoradiation therapy had good QOL yet, these results are statistically insignificant.</p> <p><strong>Conclusion:</strong> The lack of access to preventive and definitive care by the health care sectors, poor socioeconomic status, educational status of the women and awareness regarding the disease and its treatment patterns resulted in poor follow up, low adherence to the treatment, which accentuated the cervical cancer burden. Hence, enhancing the above listed factors could be beneficial in improving QOL of cervical cancer patients.</p> 2019-08-19T00:00:00+00:00 ##submission.copyrightStatement## Uterine Carcinosarcomas versus Leiomyosarcomas: DuaL Institutional Experience from Mansoura and Zagazig Universities 2019-11-20T08:09:26+00:00 Amal Halim Niveen Abo-Touk Nahla Mokhtar Hadeel Elghamery Eman Ismail Amany Hassan Hosam Halim <p><strong>Objective</strong><strong>:</strong> Carcinosarcomas (CSs) and leiomyosarcomas (LMSs) are rare uterine cancers with high mortality. This study presents a dual institutional experience from two different university teaching hospitals (Mansoura and Zagazig Universities situated in the Delta of the Nile River in Egypt) with regard to the treatment modalities of those two types of uterine cancers aimed at establishing demographics and treatment outcomes.</p> <p><strong>Patients &amp; Methods:</strong> The data from 12 uterine CS and 17 LMS patients treated at the Clinical Oncology Departments of Mansoura and Zagazig Universities from January 2012 to June 2018 were reviewed to evaluate demographics and treatment outcomes.</p> <p><strong>Results</strong><strong>: </strong>The mean age of the patients was greater than 50 years. Abnormal uterine bleeding (AUB) was the most common presenting symptom.</p> <p>Six CS (50%) patients underwent comprehensive surgical staging, while 4 patients underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH&amp;BSO). Conversely, TAH&amp;BSO was performed in 15 patients with LMS (88%).</p> <p>Adjuvant radiotherapy was given to 6 CS (50%) and 4 LMS (24%) patients. Meanwhile, adjuvant chemotherapy was received by 5 CS (42%) and 8 LMS (47%) patients. Pelvic failure occurred in only the LMS group. Visceral metastasis occurred in both groups, while bone metastasis was encountered in only the CS group. The overall survival at 5 years was 53% and 32% in patients with CS and LMS, respectively.</p> <p><strong>Conclusion</strong><strong>: </strong>AUB should be seriously investigated. Both diseases are aggressive despite early presentation and radical multimodality treatment. Local recurrence was reported in only the LMS group. Visceral metastasis occurred in both groups, unlike bone metastasis. New targeted therapies are urgently needed.</p> 2019-09-21T00:00:00+00:00 ##submission.copyrightStatement##