Management Outcome of Multi-sites Keloids of Multiple Aetiologies in a Young Female Nigerian: A Case Report
Journal of Cancer and Tumor International,
Page 52-57
DOI:
10.9734/jcti/2022/v12i3219
Abstract
Background: Keloids are exaggerated cutaneous scars with a preponderance of fibrous tissue that may complicate wound healing in people that are predisposed to its development. Its management could be challenging with very high probability of recurrence following surgical excision alone. A case of multiple keloids involving both breasts and anterior chest wall of different aetiologies in a young adult female Nigerian without family history of keloid is being reported. She had extralesional excisions of the keloids with immediate external beam radiotherapy followed by serial triamcinolone acetonide injections of the surgical sites.
Conclusion: The triple therapy of surgical excision, post-excision radiation and corticosteroid injection offers an excellent outcome in terms of recurrence.
Keywords:
- Multi-site Keloids
- extralesional excision
- radiation therapy
- steroid injection
How to Cite
References
Luo S, Benathan M, Raffoul W et al. Abnormal balance between proliferation and apoptotic cell death in fibroblasts derived from keloid lesions. Plast Reconstr Surg. 2001; 107:87–96.
Huang C, Liu L, You Z, Zhao Y, Dong J, Du Y et al. Endothelial dysfunction and mechanobiology in pathological cutaneous scarring: lessons learned from soft tissue fibrosis. Br J Dermatol. 2017;177(5):1248–1255.
Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int. J. Mol. Sci. 2017; 18:E606.
Fermoa L, Bellomoa N, Lumenta DB. Assessment of surgical strategies for addressing keloids: An optimization problem. Computers & Mathematics with Applications.2011;62(6): 2417-2423
Juckett G, Hartman-Adams H. Management of keloids and hypertrophic scars. American Family Physician. 2009;80 (3):253-260.
Berman B, Perez OA, Konda S, Kohut BE, Viera MH, Delgado S, et al.; A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management. Dermatol Surg. 2007;33 (11):1291-1303.
Omo-Dare P. Genetic studies on keloid. J Natl Med Assoc. 1975;67(6):428-432.
Brissett AE, Sherris DA. Scar contractures, hypertrophic scars, and keloids. Facial Plast Surg. 2001;17(4):263-272.
Butler PD, Longaker MT, Yang GP. Current progress in keloid research and treatment. J. Am. Coll. Surg. 2008;206(4): 731-741.
Lemperle G, Scherle J, Kitoga KE, Sachs C, Dimmler A. Keloids: Which types can be excised without risk of recurrence? A new clinical classification. Plast Reconstr Surg Glob Open. 2020; 8:1-9.
Andrews JP, Marttala J, Macarak E, Rosenbloom J, Uitto J. Keloids: The paradigm of skin fibrosis - Pathomechanisms and treatment. Matrix Biol.2016; 51:37-46.
Ajani RS, Adenipekun AA. External beam radiotherapy as an adjuvant in the management of recurrent digital heamangiomatous tumour: A case report. Journal of Cancer and Tumor International. 2021;11(3):1-6.
Ren Y, Zhou X, Wei Z, Lin W, Fan B, Feng S. Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis. International Wound Journal. 2017;14(3):480-487.
-
Abstract View: 106 times
PDF Download: 34 times
