Histopathological Characteristics of Breast Lesions in a Tertiary Health Institution in Southwest Nigeria: A 9-year Review
Journal of Cancer and Tumor International,
Page 73-80
DOI:
10.9734/jcti/2022/v12i4222
Abstract
Background: The breast is affected by several diseases, including developmental, inflammatory, and neoplastic. While benign breast neoplasms are usually more common, breast cancer is the most common nonskin cancer and the leading cause of cancer-related deaths in women after lung cancer in the world.
Objective: The review aimed to assess the histopathological diagnosis of breast lesions over a period of 9years
Methods: This was a retrospective review of eight hundred and fourteen histopathologic cases of breast lesions accessed through laboratory records of all breast lesions cases seen. The demographic data were obtained and the patient’s histology slides were reviewed. The tumors were classified according to the WHO International Classification of breast tumors and Malignant breast tumors were graded according to the Nottingham grading system. Data were analyzed using SPSS version 25.
Results: The majority of breast cancer cases were seen in patients below 40 years, malignant cases were predominant in older age groups (40 – 59 years; 57.4%, 60 years and above; 23.3%) and malignancy was significantly associated with age group, p-value < 0.05. The prevailing neoplasm was Benign type (68.3%) while malignant neoplasm accounted for 30.2% and invasive ductal carcinoma (89.1%) was most prevalent. Moreso, the majority were in grade 2; 152 (76.8%) using the Nottigham grading system. However, the commonest benign neoplasm was fibroadenoma (53.7%) followed by fibrocystic change (20.1%).
Conclusion: Breast lesions are common in this environment. Benign breast neoplasms are more commoner than malignant diseases. One in three of every sub-Saharan woman diagnosed with malignant breast lesion may not survive five years post-diagnosis. The prognosis of breast malignancies in sub-Saharan is poor due to late Presentation, ignorance, and poverty.
Keywords:
- breast lesion
- histopathology
- Ogbomoso
- Nigeria
How to Cite
References
DOI:10.1186/S12957-018-1345-2/FIGURES/7
Ezike KN, Raphael S, Okwudire-Ejeh IA, Okonkwo DI. Breast lesions in a district hospital: Demographic and histopathologic characteristics. Annals of Tropical Pathology. 2020;11(2):113.
DOI:10.4103/ATP.ATP_23_20
Kumar V, Abbas AK, Aster JC, Cotran RS, Robbins SL, Stanley L. Robbins & Cotran Pathologic Basis of Disease. 10th Ed.; 2015.
Breast Anatomy & Function: Pregnancy, Breastfeeding & Cancer.
Available:https://www.emedicinehealth.com/breast/article_em.htm
Access on November 23, 2022.
Tan PH, Ellis IO. Myoepithelial and epithelial-myoepithelial, mesenchymal and fibroepithelial breast lesions: Updates from the WHO classification of tumours of the breast 2012. J Clin Pathol. 2013;66(6):465-470.
DOI: 10.1136/jclinpath-2012-201078
Nottingham Score for Breast Cancer | Onco
Available:https://www.oncolink.org/frequently-asked-questions/cancers/nottingham-score-for-breast-cancer
Access on November 23, 2022.
Eke BA, Ojo BA, Akaa PD, Ahachi CN, Soo C, Adekwu A. The spectrum of breast diseases in nigeria north central: A histopathological survey. J Adv Med Pharm Sci. 2017;13(3):1-6.
DOI: 10.9734/JAMPS/2017/32384
Rt I, Sm S, At M, Oo O, Om M. Analysis of female breast biopsies in Usmanu Danfodiyo University Teaching Hospital (UDUTH) Sokoto, Nigeria; A ten year retrospective study. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN. 8(4):55-58.
Available:www.iosrjournals.orgwww.iosrjournals.org
Access on November 23, 2022.
Yusufu L, Odigie V, Mohammed A. Breast masses in Zaria, Nigeria. Ann Afr Med. 2004;2(1):13-16.
Available:https://www.ajol.info/index.php/aam/article/view/8270
Access on November 23, 2022.
Nwafor C, Keshinro S. The pathology of breast biopsies in a sample of Nigerian patients: Review and analysis. Annals of African Surgery. 2015;12(2).
DOI: 10.4314/aas.v12i2
Ezeome EB, Emegoakor CD, Chianakwana GU, Anyanwu S. The pattern of male breast cancer in Eastern Nigeria: A 12 year review. Nigerian Medical Journal. 2010;51(1).
DOI: 10.4314/nmj.v51i1.59861
Ahmed A, Ukwenya Y, Abdullahi A, Muhammad I. Management and outcomes of male breast cancer in Zaria, Nigeria. Int J Breast Cancer. 2012;2012:1-6.
DOI: 10.1155/2012/845143
Ugwu-Olisa OA, Nnamdi AS, Gregory NC, Festus I. Clinicopathologic study of breast lumps in Abakaliki, South Eastern Nigeria. Asian J Med Sci. 2016;7(3):58-64.
DOI: 10.3126/AJMS.V7I3.13772
Yusuf I, Atanda A, Umar A, et al. Cancer in Kano, Northwestern Nigeria: A 10-year update of the kano cancer registry. Undefined. Published online; 2017.
DOI: 10.4103/ATP.ATP_12_17
Jeje EA, Mofikoya BO, Oku YE. Pattern of breast masses in Lagos: A private health facility review of 189 consecutive patients. Nig Q J Hosp Med. 2010;20(1): 38-41.
DOI: 10.4314/NQJHM.V20I1.58015
Sahabi S, Abdullahi K. Histopathological review of male breast cancer in Sokoto, Nigeria. undefined. Published online; 2017.
DOI: 10.4103/ATP.ATP_11_17
Mandong B, Emmanuel I, Vandi K, Yakubu D. Triple negative breast cancer at the Jos University Teaching Hospital. Annals of Tropical Pathology. 2017;8(1):20.
DOI: 10.4103/ATP.ATP_14_17
Usman A, Iliyasu Y, Atanda A. Molecular subtyping of carcinoma of the female breast in a tertiary teaching hospital in Northern Nigeria. Annals of Tropical Pathology. 2019;10(1):20.
DOI: 10.4103/ATP.ATP_51_18
Bewtra C. Clinicopathologic features of female breast cancer in Kumasi, Ghana. Int J Cancer Res. 2010;6(3):154-160.
DOI: 10.3923/IJCR.2010.154.160
Ebughe GA, Ugbem TI, Ushie DE, Effewongbe S, Udosen JE, Umoh MS. Prevalence of benign breast lesions, epithelial proliferations with or without atypia in calabar-a retrospective review. Int J Trop Dis Health. 2019;8:1-7.
DOI: 10.9734/IJTDH/2019/V37I130157
An audit of 149 consecutive breast biopsies in Ibadan, Nigeria.
Available:https://pjms.com.pk/issues/aprjun108/article/article14.html
Accessed November 23, 2022
Gogo-Abite M, Nwosu SO. Histo-pathological characteristics of female breast carcinomas seen at the University of Port Harcourt Teaching Hospital, Port Harcourt Nigeria. Niger J Med. 2005;14(1): 72-76.
DOI: 10.4314/NJM.V14I1.37139
Jedy-Agba E, Curado MP, Ogunbiyi O, et al. Cancer incidence in Nigeria: A report from population-based cancer registries. Cancer Epidemiol. 2012;36(5):271-278.
DOI: 10.1016/J.CANEP.2012.04.007
Adesunkanmi ARK, Lawal OO, Adelusola KA, Durosimi MA. The severity, outcome and challenges of breast cancer in Nigeria. Breast. 2006;15(3):399-409.
DOI: 10.1016/J.BREAST.2005.06.008
Afolayan E, Ibrahim O, Ayilara G. Cancer patterns in Ilorin: An analysis of ilorin cancer registry statistics. Tropical Journal of Health Sciences. 2012;19(1).
DOI: 10.4314/tjhc.v19i1
Parsa N. Environmental factors inducing human cancers. Iran J Public Health. 2012; 41(11):1.
Access on November 25, 2022.
Henson DE, Chu KC, Levine PH. Histologic grade, stage, and survival in breast carcinoma: Comparison of African American and Caucasian women. Cancer. 2003;98(5):908-917.
DOI: 10.1002/CNCR.11558
Ibrahim IM, Iliyasu Y, Mohammed AZ. Histopathological review of breast tumors in Kano, Northern Nigeria. Sub-Saharan African Journal of Medicine. 2022;2(1):47.
DOI: 10.4103/2384-5147.150471.
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