Open Access Case study

Aggressive Angiomyxoma Presenting as a Recurrent Cervical Polyp – A Case Report

S. M. Sahabi, A. U. Adoke

Journal of Cancer and Tumor International, Page 1-6
DOI: 10.9734/JCTI/2017/34621

Backgroud: In 1983, Steeper and Rosai first described Aggressive Angiomyxoma. It is a mesenchymal neoplasm of the soft tissue that grows slowly in the pelvis and perineum and infiltrates locally. We present a case of an unusual presentation of Aggressive Angiomyxoma of the cervix uteri in a 16-year old girl.

Case Presentation: A 16-year old patient was referred on account of recurrent mass protruding per vagina 3 months after a repeat polypectomy. There were no other co-morbidities observed. She had polypectomy and subtotal hysterectomy. Histological examination showed a benign mesenchymal neoplasm that was poorly circumscribed composed of spindle shaped cells widely spaced from each other in a myxoid stroma with clustered small to medium sized vascular channels. These findings were consistent with Aggressive Angiomyxoma.

Conclusion: After thorough review of the literature, this index case is the second case reported in Africa and third in the world; other two were reported by Paplomata et al. in Greece and by Bothale K. A. et al in India, with diagnosis of Aggressive Angiomyxoma presenting as a cervical polyp. Aggressive angiomyxoma is rare, so case reports are needed to improve diagnosis and treatment.


Open Access Original Research Article

Effect of Ethanol Extract of Abrus precatorious Seed on Testosterone-Induced Benign Prostatic Hyperplasia in Adult Male Wistar Rats

I. I. Bello, O. T. Kunle-Alabi, T. F. Abraham, Y. Raji

Journal of Cancer and Tumor International, Page 1-11
DOI: 10.9734/JCTI/2017/34832

Aim: To assess the effects of Abrus precatorious seed extract on prostate weight and hormonal levels (dihydrotestosterone, testosterone and estrogen) of male Wistarrats.

Study Design: The study was divided into six groups A, B, C, D, E and F.

Place and Duration of Study: The study was conducted at Department of Physiology, College of Medicine, University of Ibadan between February and March, 2016.

Methodology: Thirty adult male rats were divided into six groups (n=5). Group A received water orally and groups C and D received 40 and 60 mg/kg of extract orally for 28 days respectively. Benign prostatic hyperplasia was induced in groups B, E and F via subcutaneous injection of 3 mg/kg of testosterone. Groups E and F received concurrently 40 and 60 mg/kg of extract orally for 28 days respectively. Hormonal levels, epididymis, testis and prostate weight were determined. Sperm analysis and histological analysis of the testis and prostate were conducted.

Results: Relative prostate weight decreased (P= .05) in groups C (0.022 ± 0.0025) and D (0.016 ± 0.0029) when compared to group A (0.0730 ± 0.0058), and in groups E (0.080 ± 0.0084) and F (0.096 ± 0.0075) when compared to group B (0.14±0.0016). The serum estrogen level decreased in groups E (16.20 ± 0.80) and F (16.40 ± 0.51) as compared to group B (19.40 ± 1.33), and also in groups C (11.80 ± 0.66) and D (11.60 ± 0.51) when compared to group A (15.20± 0.58). Prostate dihydrotestosterone levels increased in groups C and D compared to group A, and in groups E and F compared to group B. There was severe cystic prostate hyperplasia in group B.

Conclusion: Abrus precatorious seed has potential to reduce severity of testosterone-induced BPH.


Open Access Original Research Article

ABL1 is Overexpressed and Activated in Hepatocellular Carcinoma

Lennox Chitsike, Xianzhong Ding, Peter Breslin, Wei Qiu

Journal of Cancer and Tumor International, Page 1-8
DOI: 10.9734/JCTI/2017/37131

Background and Aims: ABL1 is a non-receptor tyrosine kinase of the Abelson (Abl) family, which plays an important role in cell growth, survival, invasiveness, adhesion, and migration. Despite the well-known role of BCR-ABL in hematologic malignancies, the role of ABL1 in hepatocarcinogenesis remains unknown. In this study, we want to determine if ABL1 is dysregulated in HCC.

Methods: We analyzed ABL1 mRNA in two cohorts of HCC databases from Oncomine. In addition, we performed immunohistochemistry (IHC) to examine the expression of ABL1 and p-ABL1 (Y412) in HCC tissue microarray (TMA). Further, we examined ABL1 expression and activity in oncogenes cMET/β-catenin-induced mouse HCC model.

Results: We found that ABL1 mRNA is overexpressed in over 50% of HCC. We also found that ABL1 protein expression is upregulated or activated in about 35% HCC specimens compared to adjacent normal liver. In addition, we found that ABL1 protein expression is upregulated and activated in cMET/β-catenin-induced HCC.

Conclusion: ABL1 is overexpressed and activated in human and mouse HCC. ABL1 might be a potential therapeutic target for HCC.


Open Access Original Research Article

Epidemiomorphology of Prostate Cancer in Cameroon: About 1047 Cases

Jean Paul Ndamba Engbang, Beyeme Sala, Herve Moby, Yoan Ligan, Bruno Djougmo Djimeli, Godefroy Simo, André Moune, Albert Sone Mouelle, Amadou Fewou, Jean Louis Oyono Essame, Alan Hasigov

Journal of Cancer and Tumor International, Page 1-8
DOI: 10.9734/JCTI/2017/37565

Objective: To determine the epidemiological and histological profile of prostate cancer in Cameroon.

Materials and Methods: It was a descriptive and retrospective study over a period of 12 years (2004-2015), concerning prostate cancers in five regions (Center, Littoral, West, North-west South-west). The studied parameters were frequency, age, PSA, histological type and Gleason score.

Results: We collected 1047 prostate cancers, which represented 81.42% of all urogenital cancers. The average age was 66.88 ± 9.58 years (range 32–98 years). The most affected age group was 60-79 years (736 cases), however, 3.15% (33 cases) were under 50 years. Histologically, we found a predominance of adenocarcinoma with 1044 cases (99.71%). Moderately differentiated tumors (Gleason score 7-8) represented the majority 56.56% (590 cases) of cases.

Conclusion: Prostate cancers are the predominant malignant uro-genital tumors in Cameroon. We noted the significant presence of relatively young men. Adenocarcinoma is still the main histological type. Moderately differentiated tumors are the most common.


Open Access Original Research Article

Nutritional Status of Lung Cancer Patients in Benghazi City of Libya

Faiza Nouh, Mariam Omar, Manal Younis, Moftah Younis, Rasha Mohamed, Ra'eka Gaith, Weaam Reyad

Journal of Cancer and Tumor International, Page 1-10
DOI: 10.9734/JCTI/2017/38345

Lung cancer is one of the most common type of cancer in the world and Libya is no exception. Nutrition intervention is often needed for nutrition-related complications of cancer treatment, which include but are not limited to vomiting, anorexia, nausea and, and esophagitis. The purpose of this paper is to identify the nutritional status of lung cancer patients in Benghazi city of Libya via cross-sectional study using Patient Generated Subjective Global Assessment (PG‐SGA). The study was carried out on 121 lung cancer patients. Out of 121 lung cancer patients; Only7.5% of the subjects were well nourished. 22.3% of were severe

ly malnourished; while 70.2% were either at risk of malnutrition or suspected to develop malnutrition in the future. The mean age of the subjects’ ±SD was 49.5±0.6. Age, family income, and physical activity levels were associated with nutritional status of the subjects at (P< 0.05). All sections of the PG-SGA has a significant statistical positive correlation with its total score (r = 0. 96 – 0.51, P< 0.05). Dietitians played a very limited role in patients’ nutritional care.