Open Access Case Report

External Beam Radiotherapy as an Adjuvant in the Management of Recurrent Digital Heamangiomatous Tumour: A Case Report

Rotimi Sunday Ajani, Adeniyi Abidemi Adenipekun

Journal of Cancer and Tumor International, Page 1-6
DOI: 10.9734/jcti/2021/v11i330150

Background: Heamangioma constitutes the largest subset of vascular lesions. It is predominantly congenital with predilection for the head and neck region of the body but can involve any part or region of the body. The capillary variant may be post-traumatic. After initial proliferation it may involute especially if infantile. Treatment modalities include drugs, laser and surgery. Capillary heamangioma may be refractory to drug therapy or recur after surgical excision. A case of capillary heamangioma in a middle aged male negriod (Nigerian) that developed from an ulcerated nodule over the middle phalanx of the left 4th finger with recurrence after several re-excisions is being reported. A permanent cure was achieved after a re-excision preceded by low dose external beam radiotherapy without functional compromise or altered aesthesis of the finger.

Conclusion: Post traumatic heamangioma clinically presents as hyper granulated tissue and may pose a management challenge. Arising from the excellent outcome of the low dose external beam radiation followed by excision, we hereby propose that this should be adopted as one of the treatment options of heamangiomas especially in adults.

Open Access Original Research Article

The Association between Smartphone usage and General Health in Adult Cancer Patients: A Study of the Turkish Population during the COVID-19 Pandemic

Bala Basak Oven, Abdel Rahman Nanah, Nursena Kalyenci, Umay Celik, Serkan Celik, Levent Emirzeoglu

Journal of Cancer and Tumor International, Page 7-13
DOI: 10.9734/jcti/2021/v11i330151

Aim: The aim of this study is to determine the effect of smartphone screen time on general health status of adult patients with cancer compared to healthy participants in a Turkish population amidst the COVID-19 pandemic.

Materials and Methods: 146 participants took part in this study, 81 of them were cancer patients. The mean screen time throughout their last week was obtained from the smartphones of all participants. The health status of participants was analyzed via the General Health Survey (GHS) which was a self-reported questionnaire including 12 items rated on a Likert scale. The relationship between screen time and GHS score and related factors for participants was compared.

Results: The median screen time and GHS of participants  were 180 minutes (10-945) and 13.5 (4-28), respectively. After screen time was categorized in respect to the mean of 180 minutes, A younger age (p=0.007), higher educational status (p=0.03), and early-stage disease (p=0.03) were each associated with increased screen time. Cancer stage had a correlation with GHS (add p value and correlation coefficient). While educational level was positively related with screen time (r=0.216, p=0.009), age (r=-0.471, p<0.001) and cancer stage (r=-0.332, p=0.03) were negatively correlated. Screen time was not found to be associated with GHS scores in both cancer patients and healthy participants.

Conclusion: Although smartphone usage has been increasing secondary to the dependence on social networks and increasing in-person restrictions, it did not affect the mental wellbeing among patients with cancer nor healthy participants. 

Open Access Original Research Article

Audit of Lymph Node Sampling in Colorectal Carcinoma Resections-implication for Prognosis and Management

Uchenna Simon Ezenkwa, Omenogor Alexander Odigwe, Sebastian Anebuokhae Omenai, Temitope O. Ogunsanya, Omolade O. Adegoke, Olufemi John Ogunbiyi

Journal of Cancer and Tumor International, Page 14-24
DOI: 10.9734/jcti/2021/v11i330152

Aims: To review lymph node yield in colorectal carcinoma (CRC) resections and its associated factors in a Nigerian Teaching Hospital practice.

Study design:  This was a retrospective cross-sectional study.

Place and duration of study: Department of Pathology, University College Hospital Ibadan Nigeria and colectomies from January 2014 to December 2018 were reviewed.

Methodology: Surgical Pathology reports of CRC resections at the University College Hospital Ibadan over 5 years (2014-2018) were reviewed. Colectomy lengths, tumour location (colon/rectum), tumour size, comment on presence of lymph node (yes/no), lymph node count, presence of attached mesentery (yes/no), histological subtype, tumour grade, presence of tumour-positive node and count, and pT stage were documented. Fisher’s Exact test was employed to test the effects of these variables on presence of lymph node and tumour-positive node at histology using SPSS 20. Significance level was set at P < .05.

Results: Of 66 histology reports retrieved, 62 (93.9%) had comments on search for lymph nodes and attached mesentery was documented in 25 (37.9%). The median colectomy length and tumour size were 25cm (6cm-152cm) and 6.75cm (3-30cm) respectively. Lymph nodes were present in 52 (78.8%) specimens; 28 (53.8%) of these had tumour-positive lymph nodes. Adenocarcinoma NOS was the commonest histological subtype 53 (80.3%), mucinous carcinoma 12 (18.2%) and signet ring carcinoma 1 (1.5%). Eighteen, 9 and 1of adenocarcinoma NOS, mucinous carcinoma, and signet ring carcinoma respectively had tumour-positive lymph nodes. Finding of lymph node was significantly associated with comment on search for lymph node (p < .01) while finding tumour-positive nodes was associated with histological subtype, presence of mesentery, late tumour stage and lymph node count ≥ 12 (p < .05).

Conclusion: If lymph nodes were present, more than likely there will be metastatic involvement. To increase Lymph node yield in CRC resections, submission of mesentery and search for lymph nodes is indicated. When nodes are absent, a mention is required for practice audit. It is imperative to include both clinical and grossing notes for lymph nodes to certify and guide precise staging of the cancer.

Open Access Original Research Article

Fibrous Dysplasia: A Retrospective Review of Histologically Diagnosed Cases in a Tertiary Health Care Centre in Nigeria

Philip O. Akpa, Barka V. Kwaghe, Christiana Nwanneka Ibeanu, Pricilla Ometere Onota

Journal of Cancer and Tumor International, Page 25-29
DOI: 10.9734/jcti/2021/v11i330153

Aims: This study aims to document the age, sex and site distribution of fibrous dysplasia in our tertiary health care facility in order to compare our findings with published literature.

Study Design: This is a hospital-based retrospective and descriptive study extending from 1st January 2005 to 31st December 2019.

Place and Duration of Study: Department of Histopathology, Jos University Teaching Hospital, Jos, Plateau State in North-Central Nigeria between 1st January 2005 to 31st December 2019.

Materials and Methods: Materials consisted of Archival slides, paraffin wax tissue blocks, surgical pathology register and case files of all cases of fibrous dysplasia diagnosed histologically during the period of review. The age, sex and site affected by the tumour were documented for each case using both electronic and hard copy records. The histology slides were examined to confirm the diagnosis. A total of 165 primary bone tumours (103 benign and 63 malignant) were recorded during the period of review, of which 28 were fibrous dysplasia.

Results: There were 28 cases of fibrous dysplasia which represented 17% of the primary bone tumours and 27% of the benign bone tumours. A half (50%) of the cases occurred in the second decade and 82.1% of cases were diagnosed in craniofacial bones. There was no sex bias in diagnosis.

Conclusion: Fibrous dysplasia is a relatively common bone tumour in our environment. The sex distribution, age at diagnosis, and bones affected is in keeping with findings by authors from other parts of the world.

Open Access Original Research Article

Immunohistochemical Characterization of Genes Expressed in Leiomyoma using Ki67 and P53 in Patient Attending Niger Delta University Teaching Hospital

E. F. Eruvwahwe, E. U. Eric, O. G. E. Alaba, M. B. Deele

Journal of Cancer and Tumor International, Page 30-38
DOI: 10.9734/jcti/2021/v11i330154

Objectives: This study aimed to investigate the expressions of p53 and ki67 genes in the characterization of leiomyomas.

Materials: Fifty (50) Paraffin embedded tissue blocks were selected from the department of Histopathology, Niger Delta University Teaching Hospital, Okolobri from January 2011 to August 2019. The histological characterization and morphological evaluation were defined using the routine Hematoxylin and Eosin staining method. Immunostaining was done for p53 and ki67 using the manufacturers antibodies.

Results: A direct correlation between age and the expression of the p53 gene was also made in this study. It was observed that in patients within the ages of 50-59 and 60-69, there was markedly no expression of the p53 gene whereas in patients within the ages of 20-29, there was still some level of expression (20%) and ages 30-39 (80%) and finally 40-49 (10%). There was no expression (0.0%) of Ki-67 in uterine leiomyomas across all age groups.

Conclusion; This study therefore has suggested that based on the percentage of expression, it can rightly be inferred that the p53 gene is a good indicator in the immune-histochemical characterization of leiomyomas as it has good sensitivity and good prognosis as opposed to Ki67.